84-9370-73　［取扱停止］Recombinant Human AGER protein（His tag） 20ug　PKSH500097

特徴

• 背景：Mediates interactions of advanced glycosylation end products （AGE）.
• These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes.
• Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes.
• AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.
• Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key pro-inflammatory mediators.
• Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.Receptor for amyloid beta peptide.
• Contributes to the translocation of amyloid-beta peptide （ABPP） across the cell membrane from the extracellular to the intracellular space in cortical neurons.
• ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase （MAPK）, has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.
• Can also bind oligonucleotides.