特徴
- 背景：Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity.
- IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells.
- Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells （TH1）, type 2 effector cells （TH2） and IL17 producing helper T-cells （TH17）.
- It drives rapid clonal expansion of naive but not memory CD4 T-cells.
- It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR.
- Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：＞90 ％ as determined by reducing SDS-PAGE.
- エンドトキシン濃度：Please contact us for more information.
- アクセッションNo.：Q14213＆P29459
- アミノ酸配列：Arg21-Lys229＆（GGGGS）3＆Arg23-Ser219
- 遺伝子構造：A DNA sequence encoding theHuman IL-35 protein （Q14213＆P29459） （Arg21-Lys229＆（GGGGS）3＆Arg23-Ser219） was expressed with a N-His.
- 別名（遺伝子名）：IL-27 subunit beta;IL-27B;Epstein-Barr virus-induced gene 3 protein;EBV-induced gene 3 protein
- 分子量：49.5 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4.
- 保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
- メーカーマニュアルリンク：メーカーマニュアルはこちら
- この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）
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- アズワン株式会社 試薬・プロセス材料グループ
- TEL：06-6447-8641
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- E-mail：[email protected]
商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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84-9370-71
Recombinant Human IL-35 protein（His tag） 20ug
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84-9345-33
Recombinant Human IL-35 protein（His tag） 20ug
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84-9345-34
Recombinant Human IL-35 protein（His tag） 100ug
|
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84-9370-72
Recombinant Human IL-35 protein（His tag） 100ug
|
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