84-9370-41　［取扱停止］Recombinant Human MIF protein（GST tag） 20ug　PKSH500081

特徴

• 背景：Macrophage migration inhibitory factor （MIF） is an immunoregulatory cytokine, the effect of which on arresting random immune cell movement was recognized several decades ago.
• Despite its historic name, MIF also has a direct chemokine-like function and promotes cell recruitment.
• MIF is a ubiquitously expressed protein that plays a crucial role in many inflammatory and autoimmune disorders.
• Increasing evidence suggests that MIF also controls metabolic and inflammatory processes underlying the development of metabolic pathologies associated with obesity.
• Further research has shown that MIF plays a particularly critical part in cell cycle regulation and therefore in tumorigenesis as well.
• The significance of the role of MIF in a variety of both solid and hematologic tumors has been established.
• More recently, interest has increased in the role of MIF in the development of the central nervous system （CNS） tumors, in which it appears to influence cell cycle control.
• MIF contributes to malignant disease progression on several different levels.
• Both circulating and intracellular MIF protein levels are elevated in cancer patients and MIF expression reportedly correlates with stage, metastatic spread, and disease-free survival.
• Blockade of MIF bioactivity successfully inhibited tumor cell growth in vivo and in vitro.
• MIF plays important role in the pathogenesis of gastrointestinal, hepatic, and pancreatic disorders.