84-9369-08 ［取扱停止］Recombinant Human NFATC4 protein （His Tag） 20ug PKSH500001
[Elabscience]
特徴
- 背景：Ca2+-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems.
- Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4.
- Along with NFATC3, involved in embryonic heart development.
- Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function.
- Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP （in synergy with GATA4）, NPPA/ANP/ANF and MYH7/beta-MHC.
- Involved in the regulation of adult hippocampal neurogenesis.
- Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons.
- Involved in the formation of long-term spatial memory and long-term potentiation （By similarity）.
- In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival.
- Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein （APP） .
- Plays a role in adipocyte differentiation.
- May be involved in myoblast differentiation into myotubes.
- Binds the consensus DNA sequence 5'-GGAAAAT-3' （Probable）.
- In the presence of CREBBP, activates TNF transcription.
- Binds to PPARG gene promoter and regulates its activity.
- Binds to PPARG and REG3G gene promoters.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：＞95 ％ as determined by reducing SDS-PAGE.
- エンドトキシン濃度：Please contact us for more information.
- アクセッションNo.：Q14934-1
- アミノ酸配列：Ser401-Phe683
- 遺伝子構造：A DNA sequence encoding the Human NFATC4 （Q14934-1） （401S-683F） was expressed with a polyhistidine tag at the N-terminus.
- 別名（遺伝子名）：cytoplasmic 4, NF ATc4, NF-AT3, NF-ATc4, NFAC4_HUMAN, NFAT3, NFATc4, Nuclear factor of activated T cells cytoplasmic 4, Nuclear factor of activated T cells cytoplasmic calcineurin dependent 4, Nuclear factor of activated T-cells, T cell transcription factor NFAT3, T-cell transcription factor NFAT3
- 分子量：31.5kDa
- 組成：Lyophilized from sterile PBS, pH 7.4., 5％ trehalose, 5％ mannitol, 0.01％ tween-80.
- 保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
- メーカーマニュアルリンク：メーカーマニュアルはこちら
- この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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84-9343-83
Recombinant Human NFATC4 protein （His Tag） 20ug
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84-9369-08
Recombinant Human NFATC4 protein （His Tag） 20ug
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84-9343-84
Recombinant Human NFATC4 protein （His Tag） 100ug
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