特徴
- 背景：BMP-7 （Bone morphogenetic protein 7）, also known as osteogenic protein 1 （OP-1）, is a bone morphogenetic protein which belongs to the TGF-β superfamily.
- OP-1 is expressed in the brain, kidneys and bladder.
- BMP-7 may be involved in bone homeostasis.
- Osteogenic protein 1 plays a key role in the transformation of mesenchymal cells into bone and cartilage.
- The phosphorylation of SMAD1 and SMAD5 can be induced by BMP-7, which in turn induce transcription of numerous osteogenic genes.
- BMP-7 treatment can also induce all of the genetic markers of osteoblast differentiation in many cell types.
- The expression of BMP-7 causes ventral phenotypes while its complete inhibition creates a dorsal phenotype.
- Human recombinant BMP-7 protein can be used to aid in the fusion of vertebral bodies to prevent neurologic trauma.
- It also functions in the treatment of tibial non-union, frequently in cases where a bone graft has failed.
- It is found that BMP7 has the potential for treatment of chronic kidney disease.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：＞98 ％ as determined by reducing SDS-PAGE.
- エンドトキシン濃度：＜0.1 EU per μg of the protein as determined by the LAL method.
- アクセッションNo.：P18075
- アミノ酸配列：Met315-His431
- 別名（遺伝子名）：Osteogenic Protein-1 （OP-1）
- 分子量：50.14 kDa
- 組成：Lyophilized from a solution containing 20 mM sodium citrate, 0.2 M NaCl, pH 3.5.
- 保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
- メーカーマニュアルリンク：メーカーマニュアルはこちら
- この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）
- 【試薬に関するお問合せ】
- アズワン株式会社 試薬・プロセス材料グループ
- TEL：06-6447-8641
- FAX：06-6447-8642
- E-mail：[email protected]
商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
|
84-9367-71
Recombinant Human BMP-7 protein（N-His）（active） 20ug
|
|
|
84-9367-72
Recombinant Human BMP-7 protein（N-His）（active） 100ug
|
よくあるご質問（FAQ）
掲載カタログ情報
| 掲載カタログ名 | 掲載ページ |
|---|