84-9367-03　Recombinant Human CLDN18.2（N-6His,C-Avi） 20ug　PKSH034071

特徴

• 背景：Claudin-18（CLDN18） is a protein that in humans is encoded by the CLDN18 gene.
• It belongs to the group of claudins.
• CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells.
• CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
• CLDN18 has two isoform A1 and isoform A2.IMAB362 （Claudiximab） is a monoclonal antibody against isoform 2 of Claudin-18.
• It is underinvestigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors.
• IMAB362 was developed by Ganymed Pharmaceuticals AG.

仕様

• サイズ：20ug
• 種由来：Human
• 発現宿主：E.coli
• 純度：＞95 ％ as determined by reducing SDS-PAGE.
• エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
• アクセッションNo.：P56856-2
• 遺伝子構造：Biotinylated Recombinant Human CLDN18.2 is produced by our E.coli expression system and the targetgene encoding extracellular is expressed with a 6His tag at the N-terminus.
• 別名（遺伝子名）：Claudin-18.2; CLDN18
• 分子量：12.6 kDa
• 組成：Supplied as a 0.2 μm filtered solution of 20mM Tris, 8M Urea,150mM NaCl, 5mM β-ME, pH 8.5.
• 保存条件：Store at ＜ -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
• メーカーマニュアルリンク：メーカーマニュアルはこちら
• この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）

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