背景：CD112 is a type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily.
It comprises one Ig-like V-type domain and two Ig-like C2-type domains in the extracellular region.
The V domain is believed to mediate nectin binding to its ligands.
Nectin2 is known to bind the pseudorabies virus, and herpes simplex virus2 （HSV2）, involving in cell to cell spreading of these viruses.
It does not bind poliovirus.
As a homophilic adhesion molecule, CD112 is found concentrated in adherens junctions, and exists on neurons, endothelial cells,epithelial cells and fibroblasts.
CD112 has been identified as the ligand for DNAM-1 （CD226）, and the interaction of CD226/CD112 mediates cytotoxicity and cytokine secretion by T and NK cells.
The costimulatory responses may be a critical component in allergic reactions and may therefore become targets for anti-allergic therapy.
仕様
サイズ：10ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：Q92692-2
アミノ酸配列：Gln32-Leu360
遺伝子構造：Recombinant Human Poliovirus Receptor-Related Protein 2 is produced by our Mammalian expression system and the target gene encoding Gln32-Leu360 is expressed with a mIgG2a Fc tag at the C-terminus.
組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
