背景：Interleukin-1 Receptor Accessory Protein （IL-1RAcP） is a member of the interleukin-1 receptor family.
It contains three Ig-like C2-type domains in the extracellular region and a long cytoplasmic domain implicated in signal transduction.
IL-1RAcP acts as a non-ligand binding accessory component of the receptors for IL1α, IL1βand IL33.
IL-1RAcP mediates interleukin-1-dependent activation of NF-kappa-B.
It is part of the membrane-bound form of the IL-1 receptor.
IL-1 RAcP takes part in the Signaling ways by the formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2.
In addition, IL-1RAcP modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.
仕様
サイズ：10ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：Q9NPH3
アミノ酸配列：Ser21-Glu359
遺伝子構造：Recombinant Human Interleukin-1 Receptor Accessory Protein is produced by our Mammalian expression system and the target gene encoding Ser21-Glu359 is expressed with a 6His tag at the C-terminus.
組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
