背景：Delta-like protein 1 （DLL1） is a type I transmembrane protein that belongs to the Delta/Serrate/Lag2 （DSL） family of Notch ligands.
Mature human DLL1 consists of a 528 amino acid （aa） extracellular domain （ECD） with one DSL domain and eight EGF-like repeats, a 23 aa transmembrane segment, and a 155 aa cytoplasmic domain.
Within the ECD, human DLL1 shares 91％ aa sequence identity with mouse and rat DLL1.
The residual membranebound portion of DLL1 can be cleave by presenilin-dependent γ-secretase, enabling the cytoplasmic domain to migrate to the nucleus.
DLL1 localizes to adherens junctions on neuronal processes through its association with the scaffolding protein MAGI1.
DLL1 is widely expressed, and it plays an important role in embryonic somite formation, cochlear hair cell differentiation, plus B and T lymphocyte differentiation.
The upregulation of DLL1 in arterial endothelial cells following injury or angiogenic stimulation is central to postnatal arteriogenesis.
DLL1 is also overexpressed in cervical carcinoma and glioma and contributes to tumor progression.
仕様
サイズ：10ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：O00548
アミノ酸配列：Gln18-Gly540
遺伝子構造：Recombinant Human Delta-like Protein 1 is produced by our Mammalian expression system and the target gene encoding Gln18-Gly540 is expressed with a Fc tag at the C-terminus.
別名（遺伝子名）：Delta-like protein 1; Drosophila Delta homolog 1; Delta1; H-Delta-1; DLL1
分子量：83.3 kDa
組成：Lyophilized from a 0.2 μm filtered solution of 20mM Hepes, 150mM NaCl, 1mM EDTA, pH 7.4.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
