背景：P-selectin/CD62P is a single-pass type I membrane protein which is a member of the Selectin family.
It consists 768 amino acid （aa）.
P-selectin is a cell surface glycoprotein expressed by activated platelets and endothelial cells.
It induced expression in lung, liver, kidney and heart after endotoxin treatment.
Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes.
It mediates the interaction of activated endothelial cells or platelets with leukocytes.
The ligand recognized is sialyl-Lewis X.
it also mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.
P-selectin interacts with SNX17, PSGL1/SEPL, PODXL2, mediates neutrophil adhesion and leukocyte rolling.
This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on PSGL1.
仕様
サイズ：10ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：P16109
アミノ酸配列：Trp42-Ala771
遺伝子構造：Recombinant Human P-selectin is produced by our Mammalian expression system and the target gene encoding Trp42-Ala771 is expressed with a Fc tag at the C-terminus.
別名（遺伝子名）：P-selectin; CD62 antigen-like family member P; Granule membrane protein 140; GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; PADGEM
分子量：106.9 kDa
組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
