背景：Tumor necrosis factor receptor superfamily member 10A （TNFRSF10A） is also known as TNF-related apoptosis-inducing ligand receptor 1 （TRAIL-R1）, Death receptor 4 （DR4）, CD261 and APO2, which belongs to TNF superfamily.
TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.
APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF10 / TRAIL.
This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand （TNFSF1/TRAIL）, and thus transduces cell death signal and induces cell apoptosis.
TRAIL R1 can promote the activation of NF-kappa-B.
TRAIL R1/CD261/TNFRSF1A induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types.
仕様
サイズ：10ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：O00220
アミノ酸配列：Ala24-Asn239
遺伝子構造：Recombinant Human TRAIL R1 is produced by our Mammalian expression system and the target gene encoding Ala24-Asn239 is expressed with a 6His tag at the C-terminus.
組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
