背景：SLAMF7 is a single-pass type I membrane protein and contains 1 Ig-like C2-type （immunoglobulin-like） domain.
SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines.
Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs （ITSM）, which enables to recruite signaling lymphocyte activation molecule （SLAM）-associated protein （SAP/SH2D1A）, it activates NK cells in the absence of a functional SAP.
SLAMF7 positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP.
However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function.
It was also inhibitory in T cells, which are typically devoid of EAT-2.
Thus, SLAMF7 can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.
仕様
サイズ：10ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：Q9NQ25
アミノ酸配列：Ser23-Met226
遺伝子構造：Recombinant Human SLAM Family Member 7 is produced by our Mammalian expression system and the target gene encoding Ser23-Met226 is expressed with a mFc tag at the C-terminus.
別名（遺伝子名）：SLAM Family Member 7; CD2 Subset 1; CD2-Like Receptor-Activating Cytotoxic Cells; CRACC; Membrane Protein FOAP-12; Novel Ly9; Protein 19A; CD319; SLAMF7; CS1
分子量：49 kDa
組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
