背景：K-Ras belongs to the small GTPase superfamily, Ras family.
As other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways.
It is usually tethered to cell membranes because of the presence of an isoprenyl group on its C-terminus.
K-Ras functions as a molecular on/off switch.
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
Plays an important role in the regulation of cell proliferation.
Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes （TSGs） in colorectal cancer （CRC） cells in a ZNF304-dependent manner.
Besides essential function in normal tissue signaling, the mutation of a K-Ras gene is an essential step in the development of many cancers.
Several germline K-Ras mutations have been found to be associated with Noonan syndrome[4] and cardio-facio-cutaneous syndrome.
Somatic K-Ras mutations are found at high rates in Leukemias, colon cancer, pancreatic cancer and lung cancer.
仕様
サイズ：10ug
種由来：Human
発現宿主：E.coli
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：P01116-2
アミノ酸配列：Met1-Lys169
遺伝子構造：Recombinant Human GTPase Kras4B is produced by our E.coli expression system and the target gene encoding Met1-Lys169 is expressed with a 6His tag at the N-terminus.
別名（遺伝子名）：Ki-Ras; c-K-ras; KRAS2; RASK2; CFC2
分子量：21.5 kDa
組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
