背景：Signal-regulatory protein beta-2（SIRP-beta-2）, is a monomeric single pass type I membrane glycoprotein, belongs to the SIRP/SHPS （CD172） family of the immunoglobulin （Ig） superfamily.
The SIRP family are paired receptors that have similar extracellular domains but differing C-terminal domains and functions.
A positively charged residue within the transmembrane domain, in analogy to SIRP-beta-1, is implicated to mediate interaction with the adaptor DAP12 protein, which contains immunoreceptor tyrosine-based activation motifs （ITAMs） .
Proteins in the SIRP family are typically expressed in immune cells, especially in the myeloid lineages .
Based on expression patterns, SIRPs are thought to have roles in immune regulation.
SIRP family members role in innate immunity and host defense has potential significance as a therapeutic target in cancer and inflammation.
There are currently no known mouse or rat homologs for this protein.
仕様
サイズ：10ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：Q5JXA9
アミノ酸配列：Gln33-Gly287
遺伝子構造：Recombinant Human Signal-regulatory Protein Beta-2 is produced by our Mammalian expression system and the target gene encoding Gln33-Gly287 is expressed with a Fc tag at the C-terminus.
別名（遺伝子名）：dJ776F14.2; PTPN1L; PTPNS1L3; Signal-Regulatory Protein Beta 2; Signal-Regulatory Protein Beta-2; SIRP beta 2; SIRP-beta-2; SIRPG
分子量：55.2 kDa
組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
