背景：Glypican-3/GPC3 is a member of the glypican family.
It belongs to the glypican family and is highly expressed in lung, liver, and kidney.
It is a heparan sulfate proteoglycan, which is overexpressed in various neoplasms such as hepatocellular carcinoma, malignant melanoma, and testicular yolk sac tumor, and plays an important role in cell growth and differentiation.
GPC3 function is tissue dependent.
In some tissues, GPC3 acts as a tumor suppressor gene, whereas in others, it acts as an oncofetal protein.
GPC3 is a reliable marker for hepatocellular carcinoma.
The sensitivity and specificity exceeds both alpha-fetoprotein and hepatocyte-paraffin1.
GPC3 immunohistochemistry can aid in the differentiation of testicular germ cell tumors, being expressed in all yolk sac tumors but not in seminomas.
GPC3 expression has also been identified in some squamous cell carcinomas of the lung and clear cell carcinomas of the ovary.
Glypican-3 is currently regarded as a tumor marker and potential target for immunotherapy.
仕様
サイズ：10ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞90 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：P51654
アミノ酸配列：Gln25-His559
遺伝子構造：Recombinant Human Glypican-3 is produced by our Mammalian expression system and the target gene encoding Gln25-His559 is expressed with a Fc tag at the C-terminus.
別名（遺伝子名）：Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5
分子量：87.7 kDa
組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
