背景：CD40 Ligand （CD40LG） is a type II transmembrane glycoprotein that belongs to the TNF superfamily.
Like other TNF superfamily members, CD40LG exists as a trimer in membrane bound and soluble form, both of which are bioactive.
CD40LG is a ligand for CD40; its ligation also initiates signal transduction in CD40LG expressing cells.
CD40LG is a differentiation antigen that is expressed on the surface of T-cells.
It stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines.
CD40LG has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes.
It also co-stimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL2.
仕様
サイズ：10ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞90 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：P29965
アミノ酸配列：Met113-Leu261
遺伝子構造：Recombinant Human CD40 Ligand is produced by our Mammalian expression system and the target gene encoding Met113-Leu261 is expressed with a mFc tag at the N-terminus.
組成：Lyophilized from a 0.2 μm filtered solution of PBS, 1mM EDTA, pH 7.4.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
