背景：Interleukin12 receptor subunit beta 1 （IL12RB1） is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily.
IL12RB1 can spontaneously form homodimers and -oligomers, which are able to bind IL12 with only low affinity.
IL12 high affinity receptor complex is composed of two subunits designated IL12RB1 and IL12RB2.
While IL12RB1 interacts with the IL-12p40 subunit, IL-12p35 is mainly connecting with IL12RB2.
This receptor chain is also responsible for transmitting the IL12 signal into the cell.
IL12RB1, to the contrary, is also part of the IL23R, where it interacts with the p40 subunit of IL23.
IL12RB1 is expressed in activated T cells, NK cells and B cells.
仕様
サイズ：10ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：P42701
アミノ酸配列：Cys24-Glu540
遺伝子構造：Recombinant Human Interleukin-12 Receptor Subunit Beta-1 is produced by our Mammalian expression system and the target gene encoding Cys24-Glu540 is expressed with a 6His tag at the C-terminus.
組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
