背景：Dipeptidyl peptidase-4 （DPP4） or adenosine deaminase complexing protein 2 （ADCP 2） or T-cell activation antigen CD26 is a serine exopeptidase belonging to the S9B protein family that cleaves X-proline dipeptides from the N-terminus of polypeptides, such as chemokines, neuropeptides, and peptide hormones.
The enzyme is a type II transmembrane glycoprotein, expressed on the surface of many cell types.
It is also present in serum and other body fluids in a truncated form （sCD26/DPPIV）.
The soluble CD26 （sCD26） as a tumour marker for the detection of colorectal cancer （CRC） and advanced adenomas.
As both a regulatory enzyme and a signalling factor, DPP4 has been evaluated and described in many studies.
DPP4 inhibition results in increased blood concentration of the incretin hormones glucagon-like peptide-1 （GLP-1） and gastric inhibitory polypeptide （GIP）.
This causes an increase in glucose-dependent stimulation, resulting in a lowering of blood glucose levels.
Recent studies have shown that DPP4 inhibitors can induce a significant reduction in glycosylated haemoglobin （HbA（1c）） levels, either as monotherapy or as a combination with other antidiabetic agents.
Research has also demonstrated that DPP4 inhibitors portray a very low risk of hypoglycaemia development, and are a new pharmacological class of drugs for treating Type 2 diabetes.
仕様
サイズ：50ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞70 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_001926.2
アミノ酸配列：Asn29-Pro766
遺伝子構造：The native mature form of human DPPIV （NP_001926.2） extracellular domain （Asn 29-Pro 766） was expressed and purified.
組成：Lyophilized from sterile 100mM NaCl, 50mM Tris, pH 7.5Normally 5 ％ - 8 ％ trehalose, mannitol and 0.01％ Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed manual.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
