84-9366-22　Recombinant Human CXCL2/MIP-2 Protein 20ug　PKSH033705

特徴

• 背景：Chemokine Ligand 2 （CXCL2） is a small secreted cytokine which belongs to the CXC chemokine family.
• It is secreted by monocytes and macrophages and chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells.
• CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2.
• It has been known to regulate immune functions mainly by chemo-attracting neutrophils.
• It is produced by activated monocytes and neutrophils and expressed at sites of inflammation.
• It is a hematoregulatory chemokine, which suppresses hematopoietic progenitor cell proliferation.
• It can be induced by receptor activator of NF-kappaB ligand, the osteoclast （OC） differentiation factor, through JNK and NF-kappaB signaling pathways in OC precursor cells.
• CXCL2 in turn enhanced the proliferation of OC precursor cells of bone marrow-derived macrophages （BMMs） through the activation of ERK.
• Knockdown of CXCL2 inhibited both the proliferation of and the ERK activation in BMMs.
• During osteoclastogenesis CXCL2 stimulated the adhesion and the migration of BMMs.
• CXCL2 is a novel therapeutic target for inflammatory bone destructive diseases.