特徴
- 背景：Growth Differentiation Factor 5（GDF-5, BMP-14） is a member of the BMP family of TGFβ superfamily proteins.
- Human GDF-5, -6, and -7 are a defined subgroup of the BMP family.
- GDF-5 is synthesized as a homodimeric precursor protein consisting of a 354 amino acid （aa） Nterminal proregion and a 120 aa C-terminal mature peptide.
- Mature human GDF-5 shares 99％ aa sequence identity with both mature mouse and rat GDF-5.
- GDF-5 signaling is mediated by formation of a heterodimeric complex consisting of a type 1 （BMPR-IB） and a type II （BMPR-IIor Activin RII） serine/threonine kinase receptor which results in the phosphorylation and activation of cytosolic Smad proteins （Smad1, 5, and 8）.
- GDF-5 is involved in multiple developmental processes including limb generation, cartilage development, joint formation, bone morphogenesis, cell survival, and neuritogenesis.
- Inhibition of GDF-5 expression or alteration of its signaling can facilitate the development of osteoarthritis.
仕様
- サイズ：100ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：＞95 ％ as determined by reducing SDS-PAGE.
- エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションNo.：P43026
- アミノ酸配列：Ala382-Arg501
- 遺伝子構造：Recombinant Human GDF-5 is produced by our E.coli expression system and the target gene encoding Ala382-Arg501 is expressed.
- 別名（遺伝子名）：Growth/differentiation factor 5; GDF-5; Bone morphogenetic protein 14; BMP-14; Cartilage-derived morphogenetic protein 1; CDMP-1; Lipopolysaccharide-associated protein 4; LAP-4; LPS-associated protein 4; Radotermin; CDMP1
- 分子量：13.7 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 4mM HCl.
- 保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
- メーカーマニュアルリンク：メーカーマニュアルはこちら
- この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）
- 【試薬に関するお問合せ】
- アズワン株式会社 試薬・プロセス材料グループ
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- FAX：06-6447-8642
- E-mail：[email protected]
商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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84-9366-17
Recombinant Human GDF5/BMP-14 Protein 100ug
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84-9366-16
Recombinant Human GDF5/BMP-14 Protein 20ug
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