84-9366-06　Recombinant Human Interleukin-22/IL-22 Protein （Active） 20ug　PKSH033620

特徴

• 背景：Interleukin-22（IL-22） is a member of a group of the IL-10 family; a class of potent mediators of cellular inflammatory responses.
• IL-22 is produced by activated DC and T cells.
• IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction.
• It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells.
• IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems.
• IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10.
• Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 receptor chains.
• IL-22 biological activity is further regulated by interactions with a soluble binding protein; IL-22BP.
• IL-22BP and an extracellular region of IL-22R1 share sequence similarity.
• In some cases; the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A.