84-9365-91 Recombinant Human VEGF-A/VEGF121 Protein （Active） 100ug PKSH033207
[Elabscience]
特徴
- 背景：Human VEGF121; also known as Vascular endothelial growth factor A; VEGFA; Vascular permeability factor; VPF and VEGF; is a homodimeric; heparin-binding glycoprotein which belongs to the platelet-derived growth factor （PDGF）/vascular endothelial growth factor （VEGF） family.
- VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects; including mediating increased vascular permeability; inducing angiogenesis; vasculogenesis; permeabilization of blood vessels and endothelial cell growth; increasing microvascular permeability; promoting cell migration and inhibiting apoptosis.
- Alternatively spliced transcript variants of VEGF-A encod either secreted or cell-associated isoforms.
- The lymphangiogenesis may be promoted by upregulation of VEGF121; which may in turn act in part via induction of VEGF-C.
- It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors; heparan sulfate and heparin.
- NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145.
- Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways; does not activate angiogenesis and inhibits tumor growth.
仕様
- サイズ：100ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：＞95 ％ as determined by reducing SDS-PAGE.
- エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションNo.：P15692
- アミノ酸配列：Ala27-Arg147
- 遺伝子構造：Recombinant Human Vascular Endothelial Growth Factor A is produced by our E.coli expression system and the target gene encoding Ala27-Arg147 is expressed.
- 別名（遺伝子名）：Vascular endothelial growth factor A;VEGFA;VEGF-A;Vascular permeability factor;VPF;VEGF;VEGF121
- 分子量：14.2 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS; pH7.4.
- 保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
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| 商品イメージ | アズワン品番 商品名 |
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84-9365-91
Recombinant Human VEGF-A/VEGF121 Protein （Active） 100ug
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84-9365-90
Recombinant Human VEGF-A/VEGF121 Protein （Active） 20ug
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