84-9365-76　Recombinant Human Neurturin/NRTN Protein 20ug　PKSH032804

特徴

• 背景：Neurturin is a member of the GDNF family of ligands, which include glial cell-derived neurotrophic factor （GDNF）, Neurturin, Persephin, and Artemin.
• Neurturin is expressed in both neuronal and nonneuronal tissues.
• Similarly to other TGFβ family proteins, Neurturin is synthesized as a precursor protein that is cleaved at the dibasic cleavage site （RXXR） to release the carboxyterminal domain.
• The carboxy terminal domain of Neurturin contains the characteristic seven conserved cysteine residues necessary for the formation of the cysteine-knot and the single interchain disulfide bond.
• Biologically active human Neurturin is a disulfide-linked homodimer of the carboxy-terminal 102 amino acid residues.
• Unlike other members of TGF-β family, bioactivities of all GDNF family ligands are mediated through a unique multicomponent receptor complex composed of high affinity ligand binding component （GFRα-1-GFRα-4） and a common signaling component （cRET receptor tyrosine kinase）.
• Each member of the GDNF family ligands has its preferred binding protein.
• Neurturin preferentially binds to GFRα-2 but can also bind GFRα-1 at higher concentrations.
• It may play a role in regulating the development and maintenance of the central and peripheral nervous systems and as well as non neuronal systems.