84-9365-40　Recombinant Human Galectin-8/LGALS8 Protein （Active） 20ug　PKSH032476

特徴

• 背景：The Galectin family of proteins, with specificity for Nacetyllactosaminecontaining glycoproteins, consists of beta-galactoside binding lectins containing homologous carbohydrate recognition domains （CRDs）.
• They also possess hemagglutination activity, which is attributable to their bivalent carbohydrate binding properties.
• Galectins are active both intracellularly and extracellularly.
• Although they are localized primarily in the cytoplasm and lack a classical signal peptide, galectins can also be secreted by one or more unidentified, non-classical, secretory pathways.
• They have diverse effects on many cellular functions including adhesion, migration, polarity, chemotaxis, proliferation, apoptosis, and differentiation.
• Galectins may therefore play a key role in many pathological states, including autoimmune diseases, allergic reactions, inflammation, tumor cell metastasis, atherosclerosis, and diabetic complications.
• The galectins have been classified into the prototype galectins（1, 2, 5, 7, 10, 11, 13, 14）, which contain one CRD and exist either as a monomer or a noncovalent homodimer.
• The chimera galectins（Galectin3） containing one CRD linked to a nonlectin domain, and the tandemrepeat Galectins（4, 6, 8, 9, 12） consisting of two CRDs joined by a linker peptide.Galectins lack a classical signal peptide and can be localized to the cytosolic compartments where they have intracellular functions.
• However, via one or more as yet unidentified nonclassical secretory pathways, galectins can also be secreted to function extracellularly.
• Individual members of the galectin family have different tissue distribution profiles and exhibit subtle differences in their carbohydrate-binding specificities.
• Each family member may preferentially bind to a unique subset of cell surface glycoproteins.