特徴
- 背景：FGF acidic; also known as ECGF; FGF-1and HBGF-1; is a non-glycosylated heparin binding growth factor that is expressed in the brain; kidney; retina; smooth muscle cells; bone matrix; osteoblasts; astrocytes and endothelial cells.
- It is a mitogenic peptide that is produced by multiple cell types and stimulates the proliferation of cells of mesodermal; ectodermal; and endodermal origin.
- Its association with heparan sulfate is a prerequisite for activation of FGF receptors.
- Internalized FGF acidic migrates to the nucleus where it is phosphorylated by nuclear PKC delta; exported to the cytosol; dephosphorylated; and degraded.
- Intracellular FGF acidic inhibits p53 activity and proapoptotic signaling.
仕様
- サイズ：100ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：＞95 ％ as determined by reducing SDS-PAGE.
- エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションNo.：P05230
- アミノ酸配列：Phe16-Asp155
- 遺伝子構造：Recombinant Human Fibroblast growth factor 1/Fibroblast Growth Factor Acidic is produced by our E.coli expression system and the target gene encoding Phe16-Asp155 is expressed.
- 別名（遺伝子名）：Fibroblast Growth Factor 1; FGF-1; Acidic Fibroblast Growth Factor; aFGF; Endothelial Cell Growth Factor; ECGFHeparin-Binding Growth Factor 1; HBGF-1; FGF1; FGFA
- 分子量：15.9 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM Tris; 400mM NaCl; 1mM DTT; pH 8.0 .
- 保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
- メーカーマニュアルリンク：メーカーマニュアルはこちら
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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84-9365-25
Recombinant Human FGF-1/FGFa Protein （Active） 100ug
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84-9365-24
Recombinant Human FGF-1/FGFa Protein （Active） 20ug
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