背景：Epidermal growth factor receptor 2 （HER2）, also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein, and belongs to the epidermal growth factor （EGF） receptor family.
HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively.
However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules.
HER2 plays a key role in development, cell proliferation and differentiation.
HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞90 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_004439.2
アミノ酸配列：Met 1-Thr 652
遺伝子構造：A DNA sequence encoding the extracellular domain （Met 1-Thr 652） of human ErbB2 （NP_004439.2） was fused with the polyhistidine tag at the C-terminus.
組成：Lyophilized from sterile PBS, pH 7.41. Normally 5 ％ - 8 ％ trehalose, mannitol and 0.01％ Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.2. Please contact us for any concerns or special requirements.Please refer to the specific buffer information in the hard copy of CoA.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
