背景：As a member of the epidermal growth factor receptor （EGFR） family; EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF; amphiregulin; TGF-＆alpha;; betacellulin; etc.
EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation; survival and differentiation.
Binding of a ligand induces EGFR protein homo- or heterodimerization; the subsequent tyrosine autophosphorylation and initiates various down stream pathways （MAPK; PI3K/PKB and STAT）.
In addition; EGFR signaling also has been shown to exert action on carcinogenesis and disease progression; and thus EGFR protein is proposed as a target for cancer therapy currently.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_005219
アミノ酸配列：Met 1-Gly 645
遺伝子構造：A DNA sequence encoding the extracellular domain （Met 1-Gly 645） of human EGFR （NP_005219） was fused with the Fc region of human IgG1 at the C-terminus.
別名（遺伝子名）：ERBB;ERBB1;HER1;mENA;NISBD2;PIG61
分子量：95 kDa
組成：Lyophilized from sterile PBS; pH 7.41. Normally 5 ％ - 8 ％ trehalose; mannitol and 0.01％ Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.2. Please contact us for any concerns or special requirements.Please refer to the specific buffer information in the hard copy of CoA.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
