84-9364-89　Recombinant Human BLyS/TNFSF13B/BAFF Protein （Active） 100ug　PKSH031908

特徴

• 背景：B lymphocyte stimulator （BLyS）; also known as TNFSF13B; CD257 and BAFF; is single-pass type II membrane protein; which belongs to the tumor necrosis factor family.
• BAFF is abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages.
• BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B （TACI）; TNFRSF17 （BCMA）; and TNFRSF13C （BAFFR）.
• These receptors is a prominent factor in B cell differentiation; homeostasis; and selection.
• BLyS levels affect survival signals and selective apoptosis of autoantibody-producing B cells.
• Thus; it acts as a potent B cell activator and has been shown to play an important role in the proliferation and differentiation of B cells.
• Overexpression of BLyS in mice can lead to clinical and serological features of systemic lupus erythematosus （SLE） and Sj＆ouml;gren's syndrome （SS）.
• BLyS as an attractive therapeutic target in human rheumatic diseases.
• The ability of BLyS to regulate both the size and repertoire of the peripheral B cell compartment raises the possibility that BLyS and antagonists thereof may form the basis of a therapeutic trichotomy.
• As an agonist; BLyS protein may enhance humoral immunity in congenital or acquired immunodeficiencies such as those resulting from viral infection or cancer therapy.