背景：Activin A receptor, type II-like 1 （ACVRL1）, also known as ALK-1 （activin receptor-like kinase 1）, is an endothelial-specific type I receptor of the TGF-beta （transforming growth factor beta） receptor family of ligands.
On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases.
ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development.
Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞92 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_000011.2
アミノ酸配列：Met 1-Gln 118
遺伝子構造：A DNA sequence encoding the the extracellular domain of human ALK1 （NP_000011.2） （Met 1-Gln 118） was fused with a polyhistide tag at the C-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
