背景：Agouti Related Protein （AGRP, or AGRT）, is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity.
AGRP can act as a competitive antagonist to proopiomelanocortin （POMC）-derived peptides at the melanocortin-4 receptor （MC4R）, and that this homeostatic mechanism is important as a means of coordinating appetite with perceived metabolic requirement.
AGRP is upregulated by fasting while intracerebroventricular injections of synthetic AGRP lead to increased appetite and food intake.
Thus, AGRP is a powerful orexigenic peptide that increases food intake when ubiquitously overexpressed or when administered centrally.
仕様
サイズ：50ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞90 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_001129.1
アミノ酸配列：Met 1-Thr 132
遺伝子構造：A DNA sequence encoding the human AgRP （NP_001129.1） （Met 1-Thr 132） was expressed,with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：AGRT;ART;ASIP2
分子量：14 kDa
組成：Lyophilized from sterile PBS, pH 7.2
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
