背景：CNDP1; also known as carnosine dipeptidase 1; glutamate carboxypeptidase-like protein 2 （CPGL-2） or carnosinase 1 （CN1）; is a member of the M20 metalloprotease family.
The CNDP1 gene contains trinucleotide （CTG） repeat length polymorphism in the coding region; which has been demonstrated to be associated with susceptibility to developing diabetic nephropathy; for carnosine protection against the adverse effects of high glucose levels on renal cells.
In humans; CNDP1 is secreted from the liver into the serum.
In other mammals; including rodents; CNDP1 is expressed exclusively within the kidney and lacks a signal peptide.
CNDP1 protein is a secreted homodimeric dipeptidase that specifically hydrolyzes L-carnosine （＆beta;-alanyl-L-histidine）; and is identified as human carnosinase expressed in the brain.
CNDP1 has been associated with diabetic nephropathy in Europeans and European Americans; but not African-Americans.
It was identified and confirmed as a risk factor; were cross-sectional and mostly in patients with type 2 diabetes.
The polymorphisms of CNDP1 can be excluded as a risk factor for nephropathy in type 1 diabetes.
In addition; CNDP1 is also suggested to be implicated in the actions of neuroprotection and neurotransmiting.
仕様
サイズ：50ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞90 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_116038.4
アミノ酸配列：Ser27-His507
遺伝子構造：A DNA sequence encoding the mature form of human CNDP1 （NP_116038.4） （Ser27-His507） was fused with a polyhistidine tag at the C-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
