背景：CD155; commonly known as PVR （poliovirus receptor） and Necl-5 （nectin-like molecule-5）; is a type I transmembrane single-span glycoprotein; and belongs to the nectins and nectin-like （Necl） subfamily.
CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus （PV）; an etiologic agent of the central nervous system disease poliomyelitis.
The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells.
CD155 may assist in an efficient humoral immune response generated within the intestinal immune system.
It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhension; migration and NK-cell killing; and thus efficiently prime cell-mediated tumor-specific immunity.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_006496.3
アミノ酸配列：Met 1-Asn 343
遺伝子構造：A DNA sequence encoding the human CD155 isoform a （NP_006496.3） extracellular domain （Met 1-Asn 343） was fused with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：CD155;HVED;Necl-5;NECL5;PVS;TAGE4
分子量：36.5 kDa
組成：Lyophilized from sterile PBS; pH 7.5
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
