背景：Interleukin-1 receptor antagonist （IL-1RA） also known as IL1RN is a member of the interleukin 1 cytokine family.
This protein inhibits the activities of interleukin 1; alpha （IL1A） and interleukin 1; beta （IL1B）; and modulates a variety of interleukin 1 related immune and inflammatory responses.
A polymorphism of this protein encoding gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer.
IL-1RA/IL1RN may inhibit the activity of IL-1 by binding to its receptor and it has no IL-1 like activity.
Genetic variation in IL-1RA/IL1RN is associated with susceptibility to microvascular complications of diabetes type 4 （MVCD4）.
These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus.
They include diabetic retinopathy; diabetic nephropathy leading to end-stage renal disease; and diabetic neuropathy.
Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults.
It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
Defects in IL-1RA/IL1RN are the cause of interleukin 1 receptor antagonist deficiency （DIRA） which is also known as deficiency of interleukin 1 receptor antagonist.
Autoinflammatory diseases manifest inflammation without evidence of infection; high-titer autoantibodies; or autoreactive T-cells.
DIRA is a rare; autosomal recessive; genetic autoinflammatory disease that results in sterile multifocal osteomyelitis; and pustulosis from birth.
仕様
サイズ：1mg
種由来：Human
発現宿主：E.coli
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：Please contact us for more information.
アクセッションNo.：NP_776214.1
アミノ酸配列：Arg 26-Glu 177
遺伝子構造：A DNA sequence encoding the mature form of human IL1RA isoform1 （NP_776214.1） （Arg 26-Glu 177） was expressed.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
