背景：Interleukin-1 family member 5 （IL-1F5）; also known as interleukin 36 receptor antagonist （IL36RA）; is a member of the interleukin 1 cytokine family.
This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family; member 6 （IL1F6）.
IL-1F5 is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 （IL1F9）.
IL-1F5 could constitute part of an independent signaling system analogous to interleukin-1 alpha （IL-1A）; beta （IL-1B） receptor agonist and interleukin-1 receptor type I （IL-1R1）; which is present in epithelial barriers and takes part in local inflammatory response.
It has been proved that IL-1F5 induces IL-4 mRNA and protein expression in glia in vitro and enhances hippocampal expression of IL-4 following intracerebroventricular injection.
The inhibitory effect of IL-1F5 on LPS-induced IL-1＆beta; is attenuated in cells from IL-4-defective mice.
Experiment results suggest that IL-1F5 mediates anti-inflammatory effects through its ability to induce IL-4 production and that this is a consequence of its interaction with the orphan receptor; single Ig IL-1R-related molecule （SIGIRR）/TIR8; as the effects were not observed in SIGIRR＆minus;/＆minus; mice.
In contrast to its effects in brain tissue; IL-1F5 did not attenuate LPS-induced changes; or up-regulated IL-4 in macrophages or dendritic cells; suggesting that the effect is confined to the brain.
仕様
サイズ：100ug
種由来：Human
発現宿主：E.coli
純度：＞99 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：Please contact us for more information.
アクセッションNo.：Q9UBH0
アミノ酸配列：Met 1-Asp155
遺伝子構造：A DNA sequence encoding the mature form of human IL1F5 （Q9UBH0） （Met1-Asp155） was expressed.
別名（遺伝子名）：Interleukin-36 Receptor Antagonist Protein; FIL1 Delta; IL-1-Related Protein 3; IL-1RP3; Interleukin-1 HY1; IL-1HY1; Interleukin-1 Delta; IL-1 Delta; Interleukin-1 Family Member 5; IL-1F5; Interleukin-1 Receptor Antagonist Homolog 1; IL-1ra Homolog 1; Interleukin-1-Like Protein 1; IL-1L1; IL36RN; FIL1D; IL1F5; IL1HY1; IL1L1; IL1RP3
分子量：17.1 kDa
組成：Lyophilized from sterile PBS
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
