84-9364-64　Recombinant Human IL1R1/CD121a Protein （His Tag）（Active） 1mg　PKSH031848

特徴

• 背景：Interleukin 1 receptor, type I （IL-1R1） also known as CD121a （Cluster of Differentiation 121a）, is an interleukin receptor.
• IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family.
• This protein is a receptor for interleukin alpha （IL1A）, interleukin beta （IL1B）, and interleukin 1 receptor, type I （IL1R1/IL1RA）.
• IL-1R1/CD121a is an important mediator involved in many cytokine induced immune and inflammatory responses.
• This protein has been characterized by pharmacological and molecular techniques in the mouse brain.
• The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue.
• The shape change and subsequent repair processes are IL-1＆beta; activity-dependent, acting through the IL-1 type 1 receptor （IL-1R1）, as co-application of the IL-1type 1 receptor antagonist protein （IL-1ra） blocks IL-1＆beta; induced effects.
• In the spleen, a slight increase in IL-1R AcP and IL-1R1 was observed during the first hours following LPS stimulation.
• In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found.
• However, the regulation of its expression is distinct from IL-1R1/CD121a.
• The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess.