84-9364-62　Recombinant Human PCSK1/NEC1 Protein （His Tag） 500ug　PKSH031846

特徴

• 背景：Neuroendocrine convertase 1, also known as Prohormone convertase 1, Proprotein convertase 1, PCSK1 and NEC1, is anenzyme which belongs to thepeptidase S8 family and Furin subfamily.
• PCSK1 is an enzyme that performs the proteolytic cleavage of prohormones to their intermediate （or sometimes completely cleaved） forms.
• It is present only in neuroendocrine cells such as brain, pituitary and adrenal, and most often cleaves after a pair of basic residues within prohormones but can occasionally cleave after a single arginine.
• It binds to a protein known as proSAAS, which also represents its endogenous inhibitor.
• PCSK1 is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues.
• PCSK1 substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin.
• Defects in PCSK1 are the cause of proprotein convertase 1 deficiency （PC1 deficiency）.
• PC1 deficiency is characterized by obesity, hypogonadism, hypoadrenalism, reactive hypoglycemia as well as marked small-intestinal absorptive dysfunction.
• It is due to impaired processing of prohormones.