背景：Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor and FLT1, is a single-pass type I membrane protein and secreted protein which belongs to theprotein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily.
VEGFR-1 / FLT1 is expressed mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues.
It is specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes.
VEGFR-1 / FLT1 is not expressed in tumor cell lines.
VEGFR-1 / FLT1 is an essential receptor tyrosine kinase that regulates mammalian vascular development and embryogenesis.
EGF-induced angiogenesis requires inverse regulation of VEGFR-1 and VEGFR-2 in tumor-associated endothelial cells.
VEGFR-1 / FLT1 is a receptor for VEGF, VEGFB and PGF.
It has a tyrosine-protein kinase activity.
The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：P17948-1
アミノ酸配列：Met 1-Asn 756
遺伝子構造：A DNA sequence encoding the human VEGFR1 （P17948-1） extracellular domain （Met 1-Asn 756） was expressed, fused with a polyhistidine tag at the C-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
