背景：L1 cell adhesion molecule （L1CAM）, also designated as CD171, is a cell adhesion receptor of the immunoglobulin superfamily, known for its roles in nerve cell function.
While originally believed to be present only in brain cells, in recent years L1-CAM has been detected in other tissues, and in a variety of cancer cells, including some common types of human cancer.
L1CAM interacts with a variety of ligands including axonin-1, CD9, neurocan and intergrins, and it has been revealed that the RGD motif in the sixth Ig domain of L1CAM is a binding site for integrins, thus important for nuclear signaling.
Disruption of L1CAM function causes three X-linked neurological syndromes, i.e.
hydrocephalus, MASA syndrome （mental retardation, aphasia, shuffling gait and adducted thumbs） and spastic paraplegia syndrome.
Overexpression of L1CAM in normal and cancer cells increased motility, enhanced growth rate and promoted cell transformation and tumorigenicity.
Recent work has identified L1CAM （CD171） as a novel marker for human carcinoma progression, and a candidate for anti-cancer therapy.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞85 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_000416.1
アミノ酸配列：Met 1-Glu 1120
遺伝子構造：A DNA sequence encoding the extracellular domain of human CD171 （NP_000416.1） （Met 1-Glu 1120） was fused with a polyhistidine tag at the C-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
