背景：Cathepsin Z （CTSZ）; also known as Cathepsin X or CATX; belongs to the C1 family of lysosomal cysteine proteases.
Its gene structure and activity properties show several unique features that distinguish it clearly from other human cysteine proteases.
It has a very short pro-region that shows no similarity to those of other cathepsins and a three-residue insertion motif that forms a characteristic ＆lsquo;mini loop＆rsquo;.
Cathepsin Z exhibits mono- and di-peptidase activity at its C-terminus; and in contrast to cathepsin B; it does not act as an endopeptidase.
It is restricted to the cells of theimmune system; predominantly monocytes; macrophages and dendritic cells.
Cathepsin Z is widely expressed in human tissues; suggesting that this enzyme could be involved in the normal intracellular protein degradation taking place in all cell types.
It is capable to cleave regulatory motifs at C-terminus affecting the function of targeted molecules.
Cathepsin X may regulate also the maturation of dendritic cells; a process; which is crucial in the initiation of adaptive immunity.
Furthermore; higher levels of Cathepsin Z are also found in tumour and immune cells of prostate and gastric carcinomas and inmacrophages of gastric mucosa; especially after infection by Helicobacter pylori.
Cathepsin Z is also ubiquitously distributed in cancer cell lines and in primary tumors from different sources; suggesting that this enzyme may participate in tumor progression.
仕様
サイズ：50ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：Q9UBR2
アミノ酸配列：Met 1-Val 303
遺伝子構造：A DNA sequence encoding the human CTSZ （Q9UBR2） （Met 1-Val 303） was fused with a polyhistidine tag at the C-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
