84-9364-48　Recombinant Human IL2Ra/CD25 Protein （His Tag）（Active） 1mg　PKSH031814

特徴

• 背景：CD25 （alpha-chain of IL-2 receptor, or IL2RA）, is a type I transmembrane glycoprotein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain.
• IL2RA is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself.
• However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT.
• On dendritic cells （DC）, CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.
• The IL2RA （CD25） gene is a substantial component of the high-affinity receptor molecule highly expressed by activated T lymphocytes.
• Recently, a strong evidence was obtained for the involvement of IL-2RA in conferring susceptibility to type 1 diabetes （T1D）.
• Cancer growth and development is associated with the stimulation of the innate immune system, including enhanced interleukin 2 receptor （IL-2R） expression in immune cells and its shedding into the circulation in a soluble form of sIL-2Ralpha.
• In most haematological malignancies, including different types of leukaemias and lymphomas, sIL-2Ralpha has been found to be released directly from the surface of neoplastic cells thus reflecting the tumour bulk, turnover and activity.
• Several studies have proved that not only lymphoid cancer cells, but also some non-lymphoid cancer cells, express IL-2R on their surface.
• They include malignant melanoma and carcinomas of the kidney, head and neck, oesophagus and lung.
• Thus, sIL-2Ralpha is elevated in most proliferative disturbances of the hematopoietic system and in many solid tumors.