背景：TNFRSF21 （death receptor-6; DR6） is an orphan TNF receptor superfamily member and belongs to a subgroup of receptors called death receptors.
This type I transmembrane receptor possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain.
DR6 is an extensively posttranslationally modified transmembrane protein and that N- and O-glycosylations of amino acids in its extracellular part.
DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain; and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis.
DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production; suggested that DR6 serves as an important regulatory molecule in T-helper cell activation; and is involved in inflammation and immune regulation.
DR6 is expressed ubiquitously with high expression in lymphoid organs; heart; brain and pancreas.
Some tumor cells overexpress DR6; typically in conjunction with elevated anti-apoptosis molecules.
DR6 may also be involved in tumor cell survival and immune evasion; which is subject to future investigations.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞96 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_055267.1
アミノ酸配列：Met 1-Leu 350
遺伝子構造：A DNA sequence encoding the extracellular domain （Met 1-Leu 350） of human DR6 （NP_055267.1） was expressed with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：Tumor Necrosis Factor Receptor Superfamily Member 21; Death Receptor 6; CD358; TNFRSF21; DR6
分子量：35 kDa
組成：Lyophilized from sterile PBS; pH 7.5
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
