背景：Tissue kallikrein 13 （hK13）; also known as KLK-L4 （kallikrein-like gene 4）; is a member of the human tissue kallikrein family of serine proteases having diverse physiological functions in many tissues.
The KLK13 gene resides on chromosome 19q13.3-4 along with other 14 members in a gene cluster and shares a high degree of homology.
KLK13 is a trypsin-like; secreted serine protease expressed specifically in the testicular tissue including prostate; salivary gland; breast; and testis.
Growing evidence suggests that many kallikreins are implicated in carcinogenesis and may play a role in metastasis.
KLK13 may be involved in the pathogenesis and/or progression of breast and ovary cancers; and is regarded as a novel cancer biomarker.
In addition; KLK13 interacts and forms complexes with several serum protease inhibitors; such as alpha2-macroglobulin; and its expression is regulated by steroid hormones.
仕様
サイズ：50ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_056411.1
アミノ酸配列：Met 1-Ile 262
遺伝子構造：A DNA sequence encoding the pro-form of human KLK13 （NP_056411.1） （Met 1-Ile 262） was expressed with a C-terminal polyhistidine tag.
別名（遺伝子名）：Kallikrein-13; Kallikrein-Like Protein 4; KLK-L4; KLK13; KLKL4
分子量：28.4 kDa
組成：Lyophilized from sterile PBS; pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
