84-9364-37 Recombinant Human HER3/ErbB3 Protein （His Tag）（Active） 50ug PKSH031766
[Elabscience]
特徴
- 背景：ErbB3, also known as Her3（human epidermal growth factor receptor3）, is a member of the epidermal growth factor receptor （EGFR） family of receptor tyrosine kinases.
- This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation.
- However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation.
- ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors.
- This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：＞95 ％ as determined by reducing SDS-PAGE.
- エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションNo.：NP_001973.2
- アミノ酸配列：Met 1-Thr 643
- 遺伝子構造：A DNA sequence encoding the extracellular domain （Met 1-Thr 643） of human ErbB3 （NP_001973.2） precursor was expressed, with a C-terminal polyhistidine tag.
- 別名（遺伝子名）：c-erbB-3;c-erbB3;EEBB3;ErbB-3;erbB3-S;HER3;LCCS2;MDA-BF-1;p180-ErbB3;p45-sErbB3;p85-sErbB3
- 分子量：70.2 kDa
- 組成：Lyophilized from sterile PBS, pH 7.5
- 保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
- メーカーマニュアルリンク：メーカーマニュアルはこちら
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84-9364-38
Recombinant Human HER3/ErbB3 Protein （His Tag）（Active） 500ug
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84-9364-37
Recombinant Human HER3/ErbB3 Protein （His Tag）（Active） 50ug
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