背景：Endothelin-converting enzyme 2; also known as ECE-2; is a metalloprotease that possesses many properties consistent with it being a neuropeptide-processing enzyme.
Endothelin-converting enzymes （ECEs） are the key enzymes in the endothelin （ET） biosynthesis that catalyze the conversion of big ET; the biologically inactive precursor of mature ET.
Two enzymes; termed ECE-1 and ECE-2; have been molecularly identified.
ECE-2 is found primarily in neural tissues; with high levels of expression in midbrain; cerebellum; hypothalamus; frontal cortex and spinal cord and moderate levels in hippocampus and striatum.
ECE-2 is strongly down-regulated in inferior parietal lobe from Alzheimer disease patients （at protein level）.
ECE-2 converts big endothelin-1 to endothelin-1.
It is involved in the processing of various neuroendocrine peptides; including neurotensin; angiotensin I; substance P; proenkephalin-derived peptides; and prodynorphin-derived peptides.
ECE-2 may limit beta-amyloid peptide accumulation in brain.
It may also have methyltransferase activity.
A comparison of residues around the cleavage site revealed that ECE-2 exhibits a unique cleavage site selectivity that is related to but distinct from that of ECE-1.
仕様
サイズ：50ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_055508.3
アミノ酸配列：Gly 199-Trp 883
遺伝子構造：A DNA sequence encoding the ectodomain of human endothelin converting enzyme 2 isoform A （NP_055508.3） （Gly 199-Trp 883） was fused with the Fc region of human IgG1 at the N-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
