背景：Granulocyte Colony Stimulating Factor Receptor （G-CSFR）, also known as CD114, which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3 （CSF3）.
It is a critical regulator of granulopoiesis.
This type I membrane protein has a composite structure consisting of an immunoglobulin（Ig）-like domain, a cytokine receptor-homologous （CRH） domain and three fibronectin type III （FNIII） domains in the extracellular region.
Mutations in the G-CSF receptor leading to carboxy-terminal truncation transduce hyperproliferative growth responses, and are implicated in the pathological progression of severe congenital neutropenia （SCN） to acute myelogenous leukemia （AML）.
Additionally, autocrine/paracrine stimulation of G-CSFR may be important in the biology of solid tumors, including metastasis.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_000751.1
アミノ酸配列：Met 1-Pro 621
遺伝子構造：A DNA sequence encoding the extracellular domain （Met 1-Pro 621） of human G-CSF receptor （NP_000751.1） precursor was expressed with the fused Fc region of human IgG1 at the C-terminus.
別名（遺伝子名）：CD114;CSF3R;G-CSF R;GCSFR
分子量：93.3 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
