背景：ACVR2A and ACVR2B are two activin type II receptors.
ACVR2B is integral to the activin and myostatin signaling pathway.
Ligands such as activin and myostatin bind to ACVR2A and ACVR2B.
Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A.
The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains.
Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength.
Defects in ACVR2B are a cause of left-right axis malformations.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_001097.2
アミノ酸配列：Met 1-Thr 134
遺伝子構造：A DNA sequence encoding the N-terminal segment （Met 1-Thr 134） from the extracellular domain of human ACVR2B （NP_001097.2） was expressed with the fused human IgG1 Fc region at the C-terminus.
別名（遺伝子名）：Activin Receptor Type-2B; Activin Receptor Type IIB; ACTR-IIB; ACVR2B;Bone Morphogenetic Protein Receptor Type-2; BMP Type-2 Receptor; BMPR-5; Bone Morphogenetic Protein Receptor Type II; BMP Type II Receptor
分子量：40.0 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
