背景：Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene.
It is a single-pass type I membrane protein belonging to the ephrin receptor subfamily of protein kinase superfamily.
Members of the ephrin and Eph family are local mediators of cell function through largely contact-dependent processes in development and in maturity.
Furthermore; EphB4 protein and the corresponding ligand Ephrin-B2 contribute to tumor growth in various human tumors.
EphB4 protein has tumor suppressor activities and that regulation of cell proliferation; extracellular matrix remodeling; and invasive potential are important mechanisms of tumor suppression.
Therefore; Ephrin-B2/EphB4 may be recognized as a novel prognostic indicator for cancers.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_004435.3
アミノ酸配列：Met 1-Ala 539
遺伝子構造：A DNA sequence encoding the extracellular domain （Met 1-Ala 539） of human EphB4 （NP_004435.3） precursor was expressed with the fused Fc region of human IgG1 at the C-terminus.
別名（遺伝子名）：HTK;MYK1;TYRO11
分子量：83.8 kDa
組成：Lyophilized from sterile PBS; pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
