背景：Processing of the N-terminal initiator methionine or formylated methionine is an essential cellular process conserved from prokaryotes to eukaryotes.
The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine aminopeptidases （MetAPs） and is essential for cell growth.
METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites.
As a member of the M24 family of metalloproteases, METAP1 plays an important role in G（2）/M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents.
仕様
サイズ：50ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞85 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_055958.2
アミノ酸配列：Met 1-Phe 272
遺伝子構造：A DNA sequence encoding the N-terminal domain （Met 1-Phe 272） of human METAP1 （NP_055958.2） was fused with the Fc region of human IgG1 at the N-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
