背景：ACVR2A and ACVR2B are two activin type II receptors.
ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B.
The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous （approximately 98％ identity） to the rat, mouse, and human ACVR2A proteins.
Inactivation of ACVR2A is a common event in prostate cancer cells suggesting it may play an important role in the development of prostate cancer.
The ACVR2A gene is a putative tumor suppressor gene that is frequently mutated in microsatellite-unstable colon cancers （MSI-H colon cancers）.
Frameshift mutation of ACVR2A may contribute to MSI-H colon tumorigenesis via disruption of alternate TGF-beta effector pathways.
仕様
サイズ：1mg
種由来：Human
発現宿主：HEK293 Cells
純度：＞97 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_001607.1
アミノ酸配列：Met 1-Pro 134
遺伝子構造：A DNA sequence encoding the extracellular domain of human ACVR2A （NP_001607.1） （Met 1-Pro 134） was expressed, with a polyhistidine tag at the C-terminus.
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
