背景：FcγRIIB is a low affinity receptor that recognizes the Fc portion of IgG.
The human CD32 group consists of FcγRIIA, FcγRIIB, and FcγRIIC proteins that share 94-99％ sequence identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains.
FcγRII protein is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin.
FcγRIIB has an intrinsic cytoplasmic immunoreceptor tyrosine-based inhibitory motif （ITIM） and delivers an inhibitory signal upon ligand binding.
Ligation of FcγRIIB on B cells down-regulates antibody production and in some circumstances may promote apoptosis.
Co-ligation of FcγRIIB on dendritic cells inhibits maturation and blocks cell activation.
FcγRIIB may also be a target for monoclonal antibody therapy for malignancies.
FcγRIIB plays an important negative-regulating role through modulating the signals from activation receptors.
仕様
サイズ：100ug
種由来：Human
発現宿主：HEK293 Cells
純度：＞95 ％ as determined by reducing SDS-PAGE.
エンドトキシン濃度：＜1.0 EU per μg of the protein as determined by the LAL method.
アクセッションNo.：NP_001002274.1
アミノ酸配列：Ala 46-Ile 224
遺伝子構造：A DNA sequence encoding the extracellular domain （Ala 46-Ile 224） of mature human CD32b （NP_001002274.1） protein was fused with a signal peptide at the N-terminus and a c-terminal polyhistidine tagged AVI tag at the C-terminus. The expressed protein was biotinylated in vivo by the Biotin-Protein ligase （BirA enzyme） which is co-expressed.
別名（遺伝子名）：Low Affinity Immunoglobulin Gamma Fc Region Receptor II-b; IgG Fc Receptor II-b; CDw32; Fc-Gamma RII-b; Fc-Gamma-RIIb; FcRII-b; CD32; FCGR2B; FCG2; IGFR2
分子量：24 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months.
